GRANFILLER-DExcipient for Orally Disintegrating Tablet

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White paper: HiSORAD - Solving content uniformity issues in ODT prepared by direct compression

We published a white paper titled "HiSORAD - Solving content uniformity issues in ODT prepared by direct compression ". Continuing from the previous report, a part of this study was carried out under the collaborative research project with Heinrich Heine University.

Please refer to the attached file. [article2203[daicel].pdf]


Direct compression is the simplest tableting method, contributing to both energy savings and cost advantages. However, maintaining content uniformity of active pharmaceutical ingredient (API) in tablets prepared by direct compression can be challenging. In this study, the content uniformity in low-dose ODT and low-dose mini-ODT with HiSORAD was evaluated. As the result, acceptance value for both ODTs was less than 15 complying with the specification of Ph, Eur. Furthermore, coefficient variation was less than 2%. HiSORAD is applicable not only to low-dose conventional ODT but also mini-ODT by optimizing the API size.

03/16/2022


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